The options in the Network configuration category are all to do with configuring the underlying TCP/IP network settings for this Server.
If you do not already have computers using TCP/IP on your network then you should not need to change any of these options. They are here only so the Server can be made to fit in with an existing TCP/IP infrastructure.
If you make changes to the Network configuration through the Web Browser
based Administration Pages the changes will not take effect until you re-boot,
as some of the changes could mean you will lose contact with the Server
temporarily, for example if you change the IP Address
so that the server is no longer on the same network as your PC.